Paris St Germain are sweating over striker Zlatan Ibrahimovic's fitness as the French champions look fragile ahead of Barcelona's visit in Champions League Group F on Tuesday.
Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
Barcelona extended their near-perfect start to the season when Alexis Sanchez tapped in at the far post from Neymar's clever assist to secure a 1-0 win at home to city rivals Espanyol in La Liga on Friday.
Images from the EPL matches played on Saturday
While Lyon rallied to hold Leipzig 2-2 after a Memphis Depay strike, it was the English clubs who made a mark on the night. Liverpool and Chelsea moved into the last 16 with contrasting wins and now all four English clubs, including Manchester City and Tottenham Hotspur, are in the Champions League knockouts this season.
Having absorbed the body blow of losing striker Radamel Falcao in the close season, Atletico Madrid have emerged as genuine contenders to break the title stranglehold of Real Madrid and Barcelona.
News of all that's transpired on and off the football field
AC Milan youth players subjected to alleged racist abuse; Argentine fan punches player.
Barcelona's rampant trio of Neymar, Luis Suarez and Lionel Messi all found the net at the weekend and unsung Leicester City found themselves in the record books when their England striker Jamie Vardy scored for the 11th straight game.
Manchester United's Zlatan Ibrahimovic proved his hunger for silverware has not diminished with age as the Swede's double earned a 3-2 win over Southampton in an absorbing League Cup final at Wembley.
Champions League holders Real Madrid will face former European champions Liverpool, FC Basel and debutants Ludogorets of Bulgaria following the group stage draw on Thursday.
Lionel Messi fittingly sealed Barcelona's 26th La Liga title on Saturday by coming off the bench to score the goal in a 1-0 win over Levante in front of a jubilant Nou Camp crowd, who celebrated a remarkable eighth league crown in 11 years.
Juergen Klopp got a taste of the problems at Liverpool as his first home game as manager ended in a frustrating 1-1 draw against Rubin Kazan who played more than 50 minutes with 10 men in the Europa League on Thursday.
Images from Tuesday night's UEFA Champions League group stage matches.
News of all that's transpired on and off the football field
One of the most disappointing aspects of Barcelona's failure to win major silverware last season was the lack of on-field chemistry between Lionel Messi and Neymar.
Cristiano Ronaldo bagged his first five-goal haul in Real Madrid's 9-1 hammering of Granada while title-chasing Bayern Munich and Chelsea won again in Germany and England.
Barcelona lost ground on La Liga leaders Real Madrid when their 11-match winning streak was snapped by Malaga, while Premier League pacesetters Chelsea dropped points at home to Burnley. Bayern Munich enjoyed a second-successive goalrush in the Bundesliga after routing Paderborn 6-0 while AS Roma lost ground to Serie A leaders Juventus after yet another draw. This and more from the happenings in the world of football over the weekend.
Barcelona forward Lionel Messi equalled the Champions League scoring record of 71 goals when he struck for the second time in the 76th minute of Wednesday's Group F match at Ajax Amsterdam.
Stephan El Shaarawy took a small step towards refuelling his career at Monaco when the AC Milan loanee came off the bench to rescue a late 1-1 draw against Tottenham Hotspur in the Europa League's second round of group matches on Thursday.
Manchester United are satisfied with their transfer business and under no pressure to sign a fourth player in the current window, manager Jose Mourinho said.
Lionel Messi marked his first start after injury with a goal in Barcelona's 1-1 draw at AC Milan in the Champions League on Tuesday while Fernando Torres got two as Chelsea thumped Schalke and Atletico Madrid's charge continued.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
News of all that's transpired on and off the football field.
News of all that's transpired on and off the football field
Barcelona followed up last weekend's 3-1 defeat at Real Madrid with another reverse on Saturday, squandering a host of chances to lose 1-0 at home to Celta Vigo and handing the lead in La Liga to their arch rivals.
Hegerberg hat-trick fires Lyon to fourth straight Champions League
Barcelona and Atletico Madrid led a Spanish Armada into the Champions League last 16 with home wins on Wednesday and in-form Aaron Ramsey steadied Arsenal's boat with a battling win against rocky Borussia Dortmund.
This and more from the happenings in the world of football
Here is the round-up of all the football action across Europe on the weekend
For Manchester United, the answer to a slump in form or a crisis of confidence comes in 50 pound notes. Millions of them.
Images from the Europa League matches played on Thursday
News of all that's transpired on and off the football field
Photos from the Champions League matches played across Europe on Tuesday
Ruthless Bayern Munich scored five goals in the first 35 minutes on the way to a 7-1 demolition of AS Roma on Tuesday which bore an uncanny resemblance to Germany's win over Brazil by the same score in the World Cup semi-final.
